Prostate Cancer Gene 3 Pca3

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PCA3 (Prostate Cancer Antigen 3) MLabs

(Just Now) The PCA3 test is a molecular assay that detects the mRNA expression of the DD3 gene expressed in prostate cells. In recent studies it was shown to have a specificity of 78% and a sensitivity of 57% in cancer vs. non-cancer.

https://mlabs.umich.edu/tests/pca3-prostate-cancer-antigen-3

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Prostate cancer gene 3 (PCA3): development and internal

(4 days ago) Eur Urol. 2009 Oct;56 (4):667-8. BACKGROUND: Urinary prostate cancer gene 3 (PCA3) represents a promising novel marker of prostate cancer detection. OBJECTIVE: To test whether urinary PCA3 assay improves prostate cancer (PCa) risk assessment and to construct a decision-making aid in a multi-institutional cohort with pre-prostate biopsy data.

https://www.ncbi.nlm.nih.gov/pubmed/19304372

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PCA3 Test and Prostate Cancer: What to Expect

(9 days ago) The PCA3 test measures the levels of prostate cancer gene 3. This gene is found in high levels in prostate cancer cells. The test isn’t affected by an enlarged prostate, prostatitis, or other

https://www.healthline.com/health/prostate-cancer/pca3-test

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Prostate Cancer Gene 3 (PCA3) - Prostatakrebs! E

(6 days ago) The PCA3 Assay (Prostate Cancer Gene 3; in the past referred to as PCA3DD3 or DD3PCA3) is the rst genetic diagnostic test to help solve the mentioned clinical dilemmas associated with the diagnosis of PCa. In contrast to serum PSA, PCA3 is not only prostate-speci c but also PCa-speci c (Figure 1) [14]. Messenger RNA (mRNA) of the PCA3 gene is

http://www.prostatakrebse.de/informationen/pdf/PCA3%20Brochure.pdf

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The value of urinary prostate cancer gene 3 (PCA3) scores

(1 days ago) Objective: To assess correlations between Prostate CAncer gene 3 (PCA3) levels and pathological features of radical prostatectomy (RP) specimens, which define cancer aggressiveness. Patients and methods: After digital rectal examination (DRE), first-catch urine was collected from 160 patients with localized prostate cancer.

https://pubmed.ncbi.nlm.nih.gov/22221521/

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Learn about PCA3 PCA3

(6 days ago) The Progensa PCA3 assay is an in vitro nucleic acid amplification test. 11 The assay measures the concentration of prostate cancer gene 3 (PCA3) and prostate-specific antigen (PSA) RNA molecules and calculates the ratio of PCA3 RNA molecules to PSA RNA molecules (PCA3 score) in post-DRE, first-catch male urine specimens. 11 The Progensa PCA3

http://www.pca3.org/learn-about-pca3

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The relationship between Prostate CAncer gene 3 (PCA3) …

(1 days ago) Objective: To evaluate the relationship between Prostate CAncer gene 3 (PCA3) and prostate cancer significance. Patients and methods: Clinical data from two multi-centre European open-label, prospective studies evaluating the clinical utility of the PCA3 assay in guiding initial and repeat biopsy decisions were analysed. First-catch urine was collected after digital rectal examination (three

https://pubmed.ncbi.nlm.nih.gov/21883822/

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FPPCA - Clinical: PCA3 (Prostate Cancer Antigen 3)

(5 days ago) FPPCA : Prostate cancer antigen 3 (PCA3, also known as Differential Display Code 3 or DD3) is a prostate-specific gene that was present in 95% of prostate cancer samples initially studied, and significantly over-expressed in cancer versus benign tissue. PCA3 is known to be a non-coding messenger ribonucleic acid (mRNA) with no resultant protein.

https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/75211

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How Useful is the PCA3 Urine Test for Prostate Cancer

(4 days ago) Thus, the PCA3 is “a molecular biology assay that measures the expression of PCA3 (prostate cancer gene 3) mRNA [messenger RNA] in urine samples.” [iii] The analysis gives a numeric score, and the cutoff point (“red flag”) for cancer is considered to be 35 or higher.

https://sperlingprostatecenter.com/useful-pca3-urine-test-prostate-cancer/

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Study Shows Prostate Cancer Gene 3 (PCA3) Correlates With

(8 days ago) LONDON, May 9 /PRNewswire/ -- A study published in the May 2008 issue of the peer-reviewed Journal of Urology demonstrates that the prostate cancer gene 3 (PCA3) can be used to detect and stratify stage and grade of prostate cancer.(1) Following recent calls for a more accurate test for the detection of prostate cancer,(2)(3) the results of this st

https://www.science20.com/newswire/study_shows_prostate_cancer_gene_3_pca3_correlates_with_severity_of_prostate_cancer

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USRF - PCA3: A Genetic Marker of Prostate Cancer

(5 days ago) PCA3: A Genetic Marker of Prostate Cancer. The gene could not be found in any of the existing gene databases. Bussemakers and Isaacs called their new gene DD3, referring to its appearance in the display, and they concluded that it "..might be useful in prostate cancer detection (Figure 3)."The gene was ultimately found to be over-expressed in 53 of 56 prostate cancers and absent from 18 other

http://usrf.org/news/PCA3/PCA3.html

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Prostate Cancer Gene 3 (PCA3): Development and Internal

(7 days ago) Urinary prostate cancer gene 3 (PCA3) represents a promising novel marker of prostate cancer detection. Objective To test whether urinary PCA3 assay improves prostate cancer (PCa) risk assessment and to construct a decision-making aid in a multi-institutional cohort with …

https://www.sciencedirect.com/science/article/pii/S0302283809002668

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Prostate Cancer Gene 3 (PCA3) Assay - BioVantra

(9 days ago) nucleic acid amplification test (NAAT) that detects Prostate Cancer Gene 3 (PCA3) messenger ribonucleic acid (mRNA) in male urine specimens to generate a PCA3 Score. The PCA3 Score is intended for use in conjunction with standard-of -care diagnostic algorithms as an aid in the diagnosis and prognosis of prostate cancer.

http://www.biovantra.com/files/PCA3.pdf

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PCA3 - Wikipedia

(4 days ago) PCA3. Prostate cancer antigen 3 ( PCA3, also referred to as DD3) is a gene that expresses a non-coding RNA. PCA3 is only expressed in human prostate tissue, and the gene is highly overexpressed in prostate cancer. Because of its restricted expression profile, the PCA3 RNA is useful as a tumor marker.

https://en.wikipedia.org/wiki/PCA3

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50652 - Gene ResultPCA3 prostate cancer associated 3

(9 days ago) Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer. this is the first prospective study to demonstrate lack of expression of PCA3 in CRPC, with the result apparently not influenced by chemotherapy.

https://www.ncbi.nlm.nih.gov/gene/50652

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Progensa PCA3 Assay - Hologic

(5 days ago) The Progensa PCA3 Assay is an in vitro nucleic acid amplification test (NAAT) that detects Prostate Cancer Gene 3 (PCA3) ribonucleic acid (RNA) in male urine specimens to generate a PCA3 Score. The PCA3 Score is intended for use in conjunction with standard-of-care diagnostic algorithms as an aid in the diagnosis of prostate cancer.

https://www.hologic.com/sites/default/files/package-insert/501377EN-IFU-PI_002_01.pdf

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PCA3 - Testing.com

(5 days ago) The prostate cancer antigen 3 (PCA3) test detects genetic material (messenger RNA (mRNA)) that is produced only by the prostate. The protein PCA3 and its associated mRNA are present at low levels in normal prostate tissue. PCA3 is present in increased amounts (over-expressed) in about 90% of prostate cancers.

https://www.testing.com/tests/pca3/

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PCA3 Cancer Genetics Web

(3 days ago) Gene: PCA3; prostate cancer associated 3: Aliases: DD3, PCAT3, NCRNA00019, PRUNE2-AS1 : Location: 9q21.2: Summary: This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is …

http://www.cancerindex.org/geneweb/PCA3.htm

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PCA3 — Early Detection Research Network

(9 days ago) The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. Because there is no extensive open reading frame, the gene is thought to express a noncoding RNA. The FDA has approved an assay for prostate cancer that uses the ratio of PCA3 RNA to PSA RNA in urine. The assay is used to help physicians determine the need for repeat prostate biopsies in

https://edrn.nci.nih.gov/data-and-resources/biomarkers/pca3

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FPPCA - Overview: PCA3 (Prostate Cancer Antigen 3)

(8 days ago) pca3 Aliases Lists additional common names for a test, as an aid in searching Differential Display Code 3 (DD3) PCA3 (Prostate Cancer Antigen 3) PCA3 PCA-3 Prostate Cancer Gene 3

https://www.mayocliniclabs.com/test-catalog/Overview/75211

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Performance of the Prostate Cancer Antigen 3 (PCA3) Gene

(4 days ago) Messenger RNA (mRNA) of the prostate cancer antigen 3 (PCA3)gene,formerlyknownasDD3,wasidentifiedin1999 and was found to be strongly overexpressed in >95% of primary prostate cancer (PCa) tissue specimens and PCa metastases [1]. In the absence of a protein, a nucleic acid-based test was developed to investigate the potential of

https://www.europeanurology.com/article/S0302-2838(10)00602-0/pdf/Performance+of+the+Prostate+Cancer+Antigen+3+%28PCA3%29+Gene+and+Prostate-Specific+Antigen+in+Prescreened+Men%3A+Exploring+the+Value+of+for+a+First-line+Diagnostic+Test

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Relationship between prostate cancer gene 3 (PCA3) and

(8 days ago) BACKGROUND. Data supporting prostate cancer gene 3 (PCA3) as prognostic marker are still inconsistent. With special emphasis to Gleason pattern specific tumor volumes (TVs) the relationships between PCA3 score and different characteristics of tumor aggressiveness were meticulously analyzed.

https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.22558

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PCA3 in prostate cancer and tumor aggressiveness detection

(6 days ago) Prostate cancer (PCa) is the most common male cancer in Europe and the US. The early diagnosis relies on prostate specific antigen (PSA) serum test, even if it showed clear limits. Among the new tests currently under study, one of the most promising is the prostate cancer gene 3 (PCA3), a non-coding mRNA whose level increases up to 100 times in PCa tissues when compared to normal …

https://jeccr.biomedcentral.com/articles/10.1186/s13046-015-0127-8

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Gen-Probe to initiate Phase III trial of PCA3 test in USA

(4 days ago) The prostate cancer gene 3 or PCA3 test has been available for some time under research protocols in the USA. This means that while the test has been accessible at a cost, it has not been available as a standard commercial test (in the same way as a …

https://prostatecancerinfolink.net/2009/04/29/gen-probe-to-initiate-phase-iii-trial-of-pca3-test-in-usa/

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The relationship between Prostate CAncer gene 3 (PCA3) and

(8 days ago) The PROGENSA® Prostate CAncer gene 3 (PCA3) assay is a highly prostate cancer‐specific test. PCA3 mRNA is greatly overexpressed (median 66 times) in prostate cancer tissue relative to benign tissue 2, 3.

https://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2011.10377.x

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PCA3 test for prostate cancer: What you need to know

(8 days ago) The PCA3 test may be one way to obtain more accurate results when screening for prostate cancer. PCA3 is a gene that exists in all prostate gland cells. It …

https://www.medicalnewstoday.com/articles/319675

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Prostate Cancer Gene 3 (PCA3): Development and Internal

(Just Now) Prostate cancer gene 3 (PCA3) represents a novel marker that is capable of increasing the accuracy of multivariable biopsy models. We suggest the use of our PCA3-based nomogram, which better identifies people at risk of harboring prostate cancer, to assist clinicians in deciding whether further evaluation is necessary.

https://www.europeanurology.com/article/S0302-2838(09)00266-8/fulltext

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Fluctuation in prostate cancer gene 3 (PCA3) score in men

(2 days ago) By contrast to PSA, prostate cancer gene 3 (PCA3) is a genetic marker with high specificity for PCa because it is typically overexpressed by cancer cells (it is 60–100 times more highly expressed in cancerous than in non-cancerous tissues) 2, 3. Genetic tests would be expected to yield a stable PCA3 score on repeated measures, regardless of

https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.12654

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PCA3 controls chromatin organization - Cancer Gene Therapy

(Just Now) Ochiai A, Okihara K, Kamoi K, Oikawa T, Shimazui T, Murayama S, et al. Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy. BJU Int. …

https://www.nature.com/articles/s41417-021-00314-8

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PCA3 Gene < Chromosome 9q21 Genes << Chromosome 9q …

(9 days ago) In our body's cells, the PCA3 molecule, prostate cancer antigen 3 (non-protein coding), is one of our human genes.

https://wellnessadvocate.com/?dgl=28637

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The relationship between Prostate CAncer gene 3 (PCA3) and

(6 days ago) To evaluate the relationship between Prostate CAncer gene 3 (PCA3) and prostate cancer significance. PATIENTS AND METHODS Clinical data from two multi-centre European open-label, prospective studies evaluating the clinical utility of the PCA3 assay in guiding initial and repeat biopsy decisions were analysed.

https://bjui-journals.onlinelibrary.wiley.com/doi/abs/10.1111/j.1464-410X.2011.10377.x

Category:  Prostate cancer Show Health

PCA3 noncoding RNA is involved in the control of prostate

(9 days ago) PCA3 is a non-coding RNA (ncRNA) that is highly expressed in prostate cancer (PCa) cells, but its functional role is unknown. To investigate its putative function in PCa biology, we used gene expression knockdown by small interference RNA, and also analyzed its involvement in androgen receptor (AR) signaling. LNCaP and PC3 cells were used as in vitro models for these functional …

https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-507

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Relationship between prostate cancer gene 3 (PCA3) and

(3 days ago) For instance, prostate cancer gene 3 (PCA3) [8,25], a well-illustrated classical lncRNA located in 9q21.2, has been applied to clinical practice, due to its prominent advantage in early diagnosis

https://www.researchgate.net/publication/229065510_Relationship_between_prostate_cancer_gene_3_PCA3_and_characteristics_of_tumor_aggressiveness

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pca3 prostate test PCA3 (Prostate Cancer Antigen 3) MLabs

(8 days ago) FPPCA : Prostate cancer antigen 3 (PCA3, also known as Differential Display Code 3 or DD3) is a prostate-specific gene that was present in 95% of prostate cancer samples initially studied, and … DA: 17 PA: 49 MOZ Rank: 72

https://www.keyosa.com/search/pca3-prostate-test

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Clinical evaluation of prostate cancer gene 3 score in

(8 days ago) Prostate cancer is the second most common diagnosed cancer in men. Due to the low specificity of current diagnosis methods for detecting prostate cancer, identification of new biomarkers is highly desirable. The study was conducted to determine the clinical utility of the prostate cancer gene 3 (PCA3) assay to predict biopsy-detected cancers in Chinese men.

https://bmcurol.biomedcentral.com/articles/10.1186/s12894-015-0110-x

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Clinical Evaluation of the PROGENSA(Registered Trademark

(5 days ago) Clinical Evaluation of the PROGENSA(Registered Trademark) Prostate Cancer Gene 3 (PCA3) Assay in Men With a Previous Negative Biopsy Result (PCA3) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

https://clinicaltrials.gov/ct2/show/results/NCT01024959

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Clinical Evaluation of the PROGENSA(Registered Trademark

(7 days ago) PCA3 is a gene that is highly over-expressed in more than 90% of prostate cancers, and that can be quantified in urine specimens following a digital rectal examination. Studies have shown that because PCA3 is highly specific for prostate cancer, it predicts the results of repeat biopsies more accurately than traditional prostate-specific

https://clinicaltrials.gov/ct2/show/NCT01024959

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Prostate Cancer Antigen 3 Gene Research

(4 days ago) prostate-specific antigen test is a common but controversial practice. The prostate cancer antigen-3 gene (PCA3) has recently been found to be overexpressed in prostate cancers, is measurable in urine, and may be a useful biomarker for improving the results of cancer screening programs. Objectives.

https://effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf

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Molecular diagnosis of prostate cancer: PCA3 and TMPRSS2

(4 days ago) Although several recently developed markers are promising, often showing increased specificity for prostate cancer detection compared to that of prostate specific antigen, their clinical application is limited. The only 2 true prostate cancer specific biomarkers identified to date remain PCA3 and TMPRSS2:ERG gene fusion.

https://edrn.nci.nih.gov/data-and-resources/publications/22245323-molecular-diagnosis-of-prostate-cancer

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IJMS Free Full-Text Optimization of Apta-Sensing

(7 days ago) Several other biomarkers for prostate cancer are known , including PCA3, a long non-coded RNA transcript expressed in the urine of prostate cancer patients, which appears to be an ideal biomarker of PCa . Although PCA3 was discovered a long time ago, until now, its use in prostate cancer diagnosis has been limited to the Progensa PCA assay

https://www.mdpi.com/1422-0067/22/23/12701/html

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GENE.00009 Gene Expression Profiling and Genomic Biomarker

(9 days ago) PCA3, a prostate cancer antigen gene, has been investigated as a possible additional tool in the detection of prostate cancer. The PCA3 gene (formerly known as DD3) is markedly upregulated in cancerous prostate cells and is not expressed, or expressed only at very low levels in normal or hyperplastic prostatic tissue.

https://www.anthem.com/dam/medpolicies/abcbs/active/policies/mp_pw_a049877.html

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New Urine Test ID's Prostate Cancer - WebMD

(3 days ago) It detects genetic material -- RNA -- from prostate cancer gene 3 or PCA3. PCA3 (previously known as the DD3 gene) is found only in the prostate. When prostate cells become cancerous, their PCA3

https://www.webmd.com/prostate-cancer/news/20061128/prostate-cancer-identified-by-new-urine-test?page=2

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